Publications
2026
Afanassiev, A., Wei, K. H.-C., Yachie, N., Sugioka, K., and Schiebinger, G. (2026). DemuxHMM: Large-scale single-cell embryo profiling via recombination barcoding. bioRxiv, 2026.02.23.703392. https://doi.org/10.64898/2026.02.23.703392.
Yuan, Z., Balzarini, M., Volpe, M., Goldstein, M., Peng, T.S., Hui, E., Fang, N.N., Albihlal, W.S., Hajimohammadi, M., Wei, K.H.-C., Yip, C.K., van Werven F.J., Mayor T., Weidber H. (2026). A direct role for a mitochondrial targeting sequence in signalling stress. Nature 649, 1302–1311.
2025
Keais, G.L., Saad-Roy, C.M., Gonzalez-Sqalli, E., Powell, C.N., Rieseberg, L.H., Gawryluk, R.M.R., van den Driessche, P., Wei, K.H.-C., Loppin, B., and Perlman, S.J. (2025). A selfish supergene causes meiotic drive through both sexes in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 122, e2421185122.
Huang, Y., Gao, Z.Y., Ly, K., Lin, L., Lambooij, J.-P., King, E.G., Janssen, A., Wei, K.H.-C., and Lee, Y.C.G. (2025). Polymorphic transposable elements contribute to variation in recombination landscapes. Proc. Natl. Acad. Sci. U. S. A. 122, e2427312122.
Zakerzade, R., Chang, C.-H., Chatla, K., Krishnapura, A., Appiah, S.P., Zhang, J., Unckless, R.L., Blumenstiel, J.P., Bachtrog, D., and Wei, K.H.-C. (2025). Diversification and recurrent adaptation of the synaptonemal complex in Drosophila. PLoS Genet. 21, e1011549.
2024
Kim, B.Y., Gellert, H.R., Church, S.H., Suvorov, A., Anderson, S.S., Barmina, O., Beskid, S.G., Comeault, A.A., Crown, K.N., Diamond, S.E., et al. (2024). Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life. PLoS Biol. 22, e3002697.
Betancourt, A.J., Wei, K.H.-C., Huang, Y., and Lee, Y.C.G. (2024). Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective. Annu. Rev. Genomics Hum. Genet. https://doi.org/10.1146/annurev-genom-120822-105708.
Wei, K.H.-C., Chatla, K., and Bachtrog, D. (2024). Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation. PLoS Biol. 22, e3002605.
2023
Barbash D.A., Jin B., Wei K.H.-C., Dion-Côté A-M. (2023) Testing a candidate meiotic drive locus identified by pool sequencing. G3. 2023. doi:10.1093/g3journal/jkad225
Xu, M.-R.-X., Liao, Z.-Y., Brock, J.R., Du, K., Li, G.-Y., Chen, Z.-Q., Wang, Y.-H., Gao, Z.-N., Agarwal, G., Wei, K.H.-C., et al. (2023). Maternal dominance contributes to subgenome differentiation in allopolyploid fishes. Nat. Commun. 14, 8357.
Before UBC
Wang, S., Nalley, M.J., Chatla, K., Aldaimalani, R., MacPherson, A., Wei, K.H.-C., Corbett-Detig, R.B., Mai, D., and Bachtrog, D. (2022). Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier. Proc. Natl. Acad. Sci. U. S. A. 119, e2119382119.
Wei, K.H.-C., Mai, D., Chatla, K., and Bachtrog, D. (2022). Dynamics and Impacts of Transposable Element Proliferation in the Drosophila nasuta Species Group Radiation. Mol. Biol. Evol. 39. https://doi.org/10.1093/molbev/msac080.
Wei, K.H.-C., Aldaimalani, R., Mai, D., Zinshteyn, D., Satyaki, P.R.V., Blumenstiel, J.P., Kelleher, E.S., and Brooks, E. (2022, June 1). Rethinking the “gypsy” retrotransposon: A roadmap for community-driven reconsideration of problematic gene names. OSF Preprints.
Wei, K.H.-C., Chan, C., and Bachtrog, D. (2021). Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda. Elife 10. https://doi.org/10.7554/eLife.55612.
Wei, K.H.-C., Gibilisco, L., and Bachtrog, D. (2020). Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males. Nat. Commun. 11, 5537.
Wei, K.H.-C., Mantha, A., and Bachtrog, D. (2020). The theory and applications of measuring broad-range and chromosome-wide recombination rate from allele frequency decay around a selected locus. Mol. Biol. Evol. https://doi.org/10.1093/molbev/msaa171.
Wei, K.H.-C., and Bachtrog, D. (2019). Ancestral male recombination in Drosophila albomicans produced geographically restricted neo-Y chromosome haplotypes varying in age and onset of decay. PLoS Genet. 15, e1008502.
Courret, C., Chang, C.-H., Wei, K.H.-C., Montchamp-Moreau, C., and Larracuente, A.M. (2019). Meiotic drive mechanisms: lessons from Drosophila. Proc. Biol. Sci. 286, 20191430.
Mahajan, S., Wei, K.H.-C., Nalley, M.J., Gibilisco, L., and Bachtrog, D. (2018). De novo assembly of a young Drosophila Y chromosome using single-molecule sequencing and chromatin conformation capture. PLoS Biol. 16, e2006348.
Wei, K.H.-C., Lower, S.E., Caldas, I.V., Sless, T.J.S., Barbash, D.A., and Clark, A.G. (2018). Variable Rates of Simple Satellite Gains across the Drosophila Phylogeny. Mol. Biol. Evol. 35, 925–941.
Wei, K.H.-C., Reddy, H.M., Rathnam, C., Lee, J., Lin, D., Ji, S., Mason, J.M., Clark, A.G., and Barbash, D.A. (2017). A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in Drosophila. Genetics 206, 451–465.
Wei, K.H.-C., and Barbash, D.A. (2015). Never settling down: frequent changes in sex chromosomes. PLoS Biol. 13, e1002077.
Wei, K.H.-C., Grenier, J.K., Barbash, D.A., and Clark, A.G. (2014). Correlated variation and population differentiation in satellite DNA abundance among lines of Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A. 111, 18793–18798.
Wei, K.H.-C., Clark, A.G., and Barbash, D.A. (2014). Limited gene misregulation is exacerbated by allele-specific upregulation in lethal hybrids between Drosophila melanogaster and Drosophila simulans. Mol. Biol. Evol. 31, 1767–1778.
Satyaki, P.R.V., Cuykendall, T.N., Wei, K.H.-C., Brideau, N.J., Kwak, H., Aruna, S., Ferree, P.M., Ji, S., and Barbash, D.A. (2014). The Hmr and Lhr Hybrid Incompatibility Genes Suppress a Broad Range of Heterochromatic Repeats. PLoS Genet. 10. https://doi.org/10.1371/journal.pgen.1004240.
Wei lab members in bold
